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br Conclusion the local global delicacy of change in
2018-11-02
Conclusion: the “local–global” delicacy of change in Doha׳s old center Responding to the question of adopting universal best practices without ignoring local knowledge, the three interventions integrate quality international standards while addressing local knowledge. This idea is manifested in r
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There are no evidence based guidelines to
2018-11-02
There are no evidence-based guidelines to assist the operator in treating catheter-induced aortocoronary dissection or perforation. Several factors influence the selection of treatment strategies, and the options include conservative management, stenting, and surgical intervention. Dunning et al men
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br Disclosure of funding br Introduction Traumatic brain inj
2018-11-02
Disclosure of funding Introduction Traumatic compound library injury (TBI) is a common condition that leads to significant morbidity and mortality. Approximately 33–50% of acute TBI survivors will encounter emotional lability, such as post-traumatic agitation, characterized by aggression, aka
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Obesity in general is a predisposing factor of OA
2018-11-02
Obesity in general is a predisposing factor of OA. There is a strong association between overweight and hip and knee OA. However, the association between overweight and ankle OA remains unclear. In Frey and Zamora\'s study regarding overweight and ankle OA, a total of 887 women and 535 men were incl
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Spontaneous differentiation of hESCs into different cell typ
2018-11-02
Spontaneous differentiation of hESCs into different cell types can be triggered by formation of 3-dimensional (3D) embryoid bodies (EBs) (Itskovitz-Eldor et al., 2000). Although the EB is far less organized than an embryo, it can partially mimic the spatial organization of stavudine in an embryo (Do
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Array and complete genomic hybridization based methods are n
2018-11-02
Array and complete genomic hybridization-based methods are now being used to detect deletions and amplifications that are considerably shorter than the resolution of cytogenetic techniques. Our data provides additional evidence of accrual of CNVs with extended culture, potentially as a result of rep
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dihydrochloride The goals of the current study were
2018-11-02
The goals of the current study were to investigate the changes in anal sphincter pressure after IV or IM injection of MSCs in our previously established animal models. Our models (Salcedo et al., 2010; Zutshi et al., 2009a) allow measurement of anal sphincter pressure and EMG in vivo in a repeated,
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Activin Nodal SMAD signaling is necessary
2018-11-02
Activin/Nodal-SMAD2/3 signaling is necessary and sufficient for human endoderm induction (Brown et al., 2011; D’Amour et al., 2005), but many other signaling pathways, particularly the WNT signaling pathway (Bone et al., 2011; Hay et al., 2008), also modulate DE differentiation (Mfopou et al., 2010)
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Why ectopic BRIGHT knockdown was
2018-11-02
Why ectopic BRIGHT knockdown was capable of stimulating reprogramming by the conventional 4F method but not singularly is unclear. While BRIGHT levels in MEFs are modest compared to hematopoietic tissues (Webb et al., 2011), we were only able to achieve ∼75% reduction in transcript levels (Figure S1
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The karyotype of the BIOT LOAD iPSC line
2018-11-02
The karyotype of the BIOT-4828-LOAD iPSC line was determined with Giemsa-banding, proving normal diploid 46, XX karyotype, without any detectable abnormalities (Fig. 1B). Expression of pluripotency markers was examined by immunocytochemistry staining, using vegf tyrosine kinase inhibitor against h
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br Experimental Procedures br Acknowledgments br Introductio
2018-11-02
Experimental Procedures Acknowledgments Introduction There are three distinct and differentially regulated stages in mammary gland development (embryonic, pubertal, and pregnancy/lactation), and the most substantial remodeling is postnatal (Gjorevski and Nelson, 2011). The mammary epitheliu
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br Results To develop iPSC
2018-11-02
Results To develop iPSC-based model systems of disease, we first prepared a bank of >60 iPSC clones (ten clones per donor; partial set and reprogramming methodology described previously [Mills et al., 2013; Somers et al., 2010]) derived from the dermal fibroblasts of three control individuals wit
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Genome wide screens have identified many
2018-11-02
Genome-wide screens have identified many potential regulators of stem cell function. These include genes with established roles in transcription regulation, cell growth, and differentiation, as well as genes whose function is largely unknown or remains to be validated in the context of stem cell bio
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The underlying idea of the tomographic method is in
2018-11-02
The underlying idea of the tomographic method is in reconstructing f(x, y), i.e. the density distribution function (or distribution of any other quantity) in the plane [3]. The initial data are sets of Radon images Rφ(s) that are projections of the functions f(x, y) on the set of the corresponding s
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Platelet rich plasma and other blood
2018-11-02
Platelet-rich plasma and other blood separation products have been used in human and veterinary medicine for over 20years. Numerous studies have proved the therapeutic effect of these products resulting from biological activity of the growth factors contained in platelets. Platelets are known to co
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