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br EphB as a therapeutic target in aerodigestive cancers
2020-08-08
EphB4 as a therapeutic target in aerodigestive cancers Pharmacologically targeting EphB4 Biomarker potential Comparatively speaking, very little is known about the potential of EphB4 as a biomarker, especially in upper aerodigestive malignancies. A recent study by Yu et al. [75] who evaluat
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br Materials and methods br Results
2020-08-08
Materials and methods Results Discussion This work presents several novel findings: (1) In the striatum of the ICH brain, EP1R is expressed primarily in neurons and axons, not in astrocytes or Cx3cr1+ microglia; (2) in middle-aged male mice subjected to the collagenase ICH model, EP1R activ
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However we know little about the mechanism leading
2020-08-07
However, we know little about the mechanism leading to the expression of autoantibodies in women with preeclampsia. It has recently been shown that infusion of interleukin 17 leads to hypertension and increases the production of AT1-AA in normal pregnant rats [16]; also, the infusion of soluble mous
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At the time of analysis patients
2020-08-07
At the time of analysis, 17 patients experienced disease progression. We managed to collect nine tissue samples and 14 plasma samples. Most common reason we were not able to obtain as many tissue samples as expected was difficulty in obtaining tissue samples due to invasiveness and patients’ poor co
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Our previous studies have utilised
2020-08-07
Our previous studies have utilised the chromenone triflate derivative as a key reagent for the preparation of 8-substituted chromenone libraries, employing Suzuki–Miyaura palladium-catalysed cross-coupling reactions., , , This strategy was also amenable for the synthesis of the target substituted
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br Results br Discussion Taking advantage of the
2020-08-06
Results Discussion Taking advantage of the highly specific protein–protein interactions among cognate AS-252424 that mediate SUMO conjugation to substrates, we have developed a novel strategy for achieving inhibition of SUMO conjugation in vivo based on disruption of SUMO E1–E2 interactions.
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Recent genome wide methylation studies also revealed
2020-08-06
Recent genome wide methylation studies also revealed that DNA methylation in peripheral leukocytes related to both aging and AD and could be exploited for identification of AD biomarkers (Li et al., 2016). Circulating leukocytes play an important role in the innate immune response against pathogens
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Spadin br Experimental section br Results
2020-08-06
Experimental section Results Discussion In our previous work (Rashidi et al., 2018) we isolated a novel glucarpidase whose raised Spadin did not cross-react with the one in clinical use. In principle, therefore, it would be possible to delay the production of antibodies in a patient by alt
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Grabocka et al demonstrate that depletion of HRAS or NRAS
2020-08-06
Grabocka et al. (2014) demonstrate that depletion of HRAS or NRAS leads to an increase in inhibitory phosphorylation of CHK1 at S280 and a decrease of phospho-CHK1 at S317 and S345 without affecting the ATM-CHK2 signaling pathway. Consistent with checkpoint mitigation after suppression of WT RAS iso
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In recent years many studies
2020-08-05
In recent years, many studies have found that a series of miRNAs, such as miR-17-5p, miR-26a, miR-34a, miR-133b, miR-150, and miR-370, exhibit abnormal hydralazine hcl in osteosarcoma cells. In the investigation into the CUL4B overexpression mechanism, we found that 9 out of 20 miRNAs that were pre
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The inhibition of CYP activity
2020-08-05
The inhibition of CYP11β activity by NOR was 11- and 2.5-fold higher than those reported for the antifungal agents ketoconazole (IC50: 4.4μM) and clotrimozole (IC50: 1.0μM) (Fernandes and Porte, 2013). Furthermore, NOR was able to inhibit P450 aromatase activity in carp ovaries, although at a rather
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hth 7 in 1 br Conflict of interest br Introduction The nucle
2020-08-05
Conflict of interest Introduction The nuclear receptor superfamily consists of transcription factors that depend on ligands for their activation and a larger group of transcription factors with unidentified ligands or no ligand requirement (reviewed in Mangelsdorf et al., 1995). This latter gr
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The frequency of hypermethylation of
2020-08-04
The frequency of hypermethylation of RARbeta, RASSF1A, FHIT, GSTP1, MGMT, VHL and DAPK in patients with primary LSCC was assessed in both the tumor tissue samples and macroscopically and histologically normal mucosa from distant sites of the surgical specimen, FPS-ZM1 mg and trachea. Table 2 shows
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The initial SAR conducted indicated that a
2020-08-04
The initial SAR conducted indicated that a pyridine ring was broadly tolerated in domain C so we assessed the impact of introducing a pyridine in domain B (). Exchanging the pyridine ring between domains ( vs. ) led to a balanced profile at both receptors. Maintaining phenyl rings in both domains ()
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The Val Val group also exhibited
2020-08-04
The Val/Val group also exhibited greater problems in spatial working memory than the Met/Met group, in terms of the number of errors made. These data are consistent with those found in mice using a spontaneous alternation task as well as data from human studies which have shown better performance by
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