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DDR upregulation in patients with kidney diseases
2020-05-20
DDR1 upregulation in patients with kidney diseases such as lupus nephritis and Goodpasture\'s syndrome [8] as well as in animal models of kidney injury [7], [8], [18] suggests that DDR1 plays an important role in kidney disease. Studies in various mouse models of kidney injury indicate that DDR1 del
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Examination of Wnt signaling via for
2020-05-20
Examination of Wnt signaling via, for example, complexes of frizzled (Fz) and lipoprotein-receptor-related protein (LRP) receptors has been hindered by difficulties in producing Wnt ligands due to their inherent hydrophobicity [20]. This bottleneck was recently bypassed by constructing highly solubl
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Drug drug interactions are frequently attributed to function
2020-05-20
Drug-drug interactions are frequently attributed to functional alterations in CYP enzymes, including inhibition and induction (Chen et al., 2014, Wang et al., 2013). Mechanism-based inhibition is an irreversible form of enzyme inhibition and could form a stable inhibitor-enzyme complex, which is tho
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br Methods br Discussion In a recent
2020-05-19
Methods Discussion In a recent survey among 2625 high risk patients on atorvastatin, 10.5% of patients achieved an LDL-target of CA-074 Me level for improvement of acceptance and adherence to effective lipid lowering therapy are warranted to maximize the benefits of standard treatment options
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Poziotinib Hyaluronic acid HA also called hyaluronan is wide
2020-05-19
Hyaluronic Poziotinib (HA), also called hyaluronan is widely distributed in Extra Cellular Matrix of soft connective tissues including skin, umbilical cord and synofial fluid (Hanamura et al., 2008). Hyaluronic acid has a unique ability to hold 6000mL of water in 1mg of HA and plays an important ro
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br Acknowledgements br Introduction In Arabidopsis thaliana
2020-05-18
Acknowledgements Introduction In Arabidopsis thaliana (L.) Heynh, there are at least four copies of the caseine kinase-like gene Ck1, which is involved in peptide phosphorylation in mammals [1]. These genes are distributed on NPPB 1, 2, 4, and 5. A similar number of copies for Ck1 have been i
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br Conflict of interest br
2020-05-18
Conflict of interest Acknowledgements This work was supported in part by JSPS KAKENHI Grant Number 26292031. We thank Nissan Chemical Industries, Ltd. for the gift of the sample of fluralaner. Introduction As one of the most common cancers in southern China and southeast Asia, nasopharynge
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Although many of the genetic changes remain to be
2020-05-18
Although many of the genetic changes remain to be elucidated, there is evidence to support a difference in incidence and rate of rupture of cerebral aneurysms between men and women, and between pre- and postmenopausal women, suggesting that aneurysm formation may be affected by hormonal changes.18,
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In this study we detected the
2020-05-18
In this study, we detected the PAX3/7–FOXO1 fusion DPQ in 50% of the ARMS samples, 40% PAX3–FOXO1 and 10% PAX7–FOXO1. This detection confirmed the histological diagnosis and adds to its new information that can be useful in the prognosis evaluation of ARMS patients, since the patients with PAX3/7–F
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Upon Edn ligand binding endothelin receptors
2020-05-18
Upon Edn ligand binding, endothelin receptors can induce a variety of intracellular signaling cascades leading to diverse cellular responses such as contraction in the case of smooth muscle cells, or cell growth and mitogenesis. Ednrs are expressed in a variety of cell types and tissues, for example
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The idea that ASB can drive
2020-05-18
The idea that ASB11 can drive compartment expansion in the CNS is further supported by in vitro work in human neuronal precursors. Nerve growth factor (NGF)-induced differentiation of PC12 pheochromocytoma 5959 [11] and RA-induced human pluripotent teratocarcinoma carcinoma (NT2) cells [12] constit
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What does this mean for cancer therapy We
2020-05-18
What does this mean for cancer therapy? We found that components of the de novo pyrimidine synthesis pathway rarely mutate in cancer, clearly showing its importance. In our experimental models, the pathway, including DHODH itself, was primed to respond when the block in CoQ redox-cycling was remove
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The DDR gene located on chromosome region
2020-05-18
The DDR1 gene, located on chromosome region 6p21.33, encodes a transmembrane tyrosine kinase receptor involved in melanocyte anchoring through binding to collagen IV (Silva de Castro et al., 2010). So far, only three studies have been conducted on the association between DDR1 polymorphism and the ri
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br Results and Discussion br
2020-05-18
Results and Discussion Materials and Methods Acknowledgements Introduction Among the solid tumors, Prostate cancer (PCa) has been one of the most frequently diagnosed malignancy in men and the second male\'s cancer related deaths in the developed countries [1]. In China, the incidence an
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br Experimental br Declaration of
2020-05-18
Experimental Declaration of interest Introduction Material and methods Results and discussion Conclusion By screening the NMR AS1842856 sale library an initial hit was found for an inhibitor of the PPI between the α-β subunits of CK2 with an IC50 of 900 μM. This compound was modifi
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