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Binding affinity was measured by a scintillation proximity
2020-03-25
Binding affinity was measured by a scintillation proximity binding assay using [H]4-OHT (ERRγ) or [H]estradiol (ERα/β) as radioligand. In all cases, the ERβ affinity was not significantly different from ERα. Compounds were compared to , which showed high affinity for both receptors and moderate (six
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br Acknowledgement br Introduction Recent developments
2020-03-24
Acknowledgement Introduction Recent developments in cancer immunotherapies have demonstrated durable responses, suggesting that effective immunotherapy would hold promise to improve patient outcome (Gunturu et al., 2013; Hodi et al., 2003; Lutz et al., 2011; Ribas et al., 2009). However, attem
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Central to the mechanism of cold I R
2020-03-24
Central to the mechanism of cold I/R-associated liver injury is the activation of the pro-inflammatory cascade resulting in the release of pro-inflammatory cytokines. In agreement with the present study, serum and hepatic mRNA levels of TNF-α, IL-6, and ICAM-1 were all significantly up-regulated ear
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As discussed in the introduction many pregnant women
2020-03-24
As discussed in the introduction, many pregnant women take medications such as nifedipine and indinavir, which are considerably metabolized by CYP3A [26]. Previous reports have also shown increased CYP3A activity following pregnancy [7], [9], which is consistent with our results. However, previous s
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br Clinical potential of ET receptor biased ligands Is there
2020-03-24
Clinical potential of ET receptor biased ligands Is there a clinical need for ET receptor biased ligands? Evidence is strongest from research in epithelial ovarian cancer demonstrating that ET-1 stimulated ETA-mediated β-arrestin signalling leads to activation of the oncogenic mediator NF-κB [21]
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We can think of two ways in which
2020-03-24
We can think of two ways in which collagen binding could activate DDR (Figure 8). A single collagen triple helix could interact with both DS domains in the DDR dimer (“composite binding site”) and thereby activate the receptor, similar to the situation exemplified by the growth hormone-growth hormon
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br Materials and methods br Results br
2020-03-23
Materials and methods Results Discussion Natural compounds and their derivatives have been investigated as candidates for the treatment of bone diseases and can also be the sources of nutraceutical agents and therapeutic agents [28]. Using peptides as therapeutic effects on bone-related dis
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br Introduction DNA dependent protein kinase DNA
2020-03-23
Introduction DNA-dependent protein kinase (DNA-PK) is a multicomponent serine/threonine protein kinase and considered a member of the phosphatidylinositol (PI) 3-kinase related kinase (PIKK family). This enzyme plays a critical role in the repair of mammalian DNA double strand breaks (DSBs) throu
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Indeed a significant difference was observed for the binding
2020-03-23
Indeed, a significant difference was observed for the binding of glycated α-synuclein. Thus, g-α-synuclein bound to other part of GAPDH in 4 of 10 simulations (Fig. 2F, brown, yellow and dark-green chains, and Fig. 2G, brown chain). This additional binding site is located on the interface between O
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Introduction Cytochrome P CYP A is the most important enzyme
2020-03-23
Introduction Cytochrome P450 (CYP)3A is the most important enzyme involved in the metabolism of 30–40% of currently prescribed drugs [1]. The mth1 pathway level and activity of CYP3A show large intra- and inter-individual variability, which contributes to unpredictable drug response and toxicity.
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br Conclusions and future directions In recent years
2020-03-23
Conclusions and future directions In recent years we saw major advances in our knowledge of H2A-DUB biology, with discovery of novel mammalian H2A-DUBs, better understanding of their biochemical properties, and development of several animal models to address their in vivo functions. However at pr
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All tested antibodies exhibited positive
2020-03-23
All tested pitavastatin exhibited positive immunoreactivity in NSCLC tumors, with N’-epitope being the less expressed (both as overall positivity and number of positive cases, or intensity combined with number of positive cells, as provided by H-Score. This result is in accordance with previous stu
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Studies of Jelski and Szmitkowski
2020-03-23
Studies of Jelski and Szmitkowski show that differences of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activity between Wnt-C59 of many cancers and healthy tissue may be one of the factors intensifying carcinogenesis [7]. Moreover, changes of ADH and ALDH activity in cancer cells a
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Presumably LBPs have health promoting
2020-03-23
Presumably, LBPs have health-promoting activities, such as antioxidant, immune regulation, anti-stress, anticancer, neuroprotective and antidiabetic activities [[7], [8], [9], [10], [11]]; LBPs can improve the whole-body health status of mice and stimulate the expressions of IL-2, IL-12 and TNF-α, w
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br The LSCP model and its
2020-03-21
The LSCP model and its properties In this section, we first introduce the LSCP model in Section 2.1. Some examples of the model are presented in Section 2.2 and basic properties of the model are presented in Section 2.3. Finally, Section 2.4 introduces finite dimensional approximations necessary
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