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2×Taq PCR Master Mix(with dye) RCT pathway plays a crit
2019-11-06
RCT pathway plays a critical role in the maintenance of cholesterol homeostasis by facilitating the cholesterol clearance and cholesterol efflux (Levinson & Wagner, 2015). In the process of RCT, ABCA1 and ABCG1 played as crucial regulators in cholesterol efflux (Yasuda et al., 2011). Compared with h
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Ten non FH ADH probands fulfilled the
2019-11-06
Ten non-FH ADH probands fulfilled the diagnostic criteria of hyperabsorbers. Table 2 shows the main lipid characteristics of these subjects and of 10 non-hyperabsorber probands used for comparison. There were differences between groups in body mass index, waist circumference and triglycerides. Other
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In most cases the ligand affinity between subtypes
2019-11-06
In most cases, the ligand affinity between subtypes is similar, but their tissue distribution is different. In the case of the estrogen receptors (ER), two subtypes (ERα and ERβ) exist (Kuiper et al., 1996) and ERβ has several isoforms, designated ERβ1–5 (Moore et al., 1998) or ERβcx (Ogawa et al.,
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The eNOS bp VNTR polymorphism has been found
2019-11-06
The eNOS 27-bp VNTR polymorphism has been found to be associated with altered plasma NO levels. This polymorphism also has been associated with many vascular diseases including hypertension, diabetic retinopathy, and diabetic nephropathy in various populations. Notably, our results were different fr
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br Enzyme catalysis A biochemically spontaneous process proc
2019-11-06
Enzyme catalysis A biochemically spontaneous process proceeds in a direction where free amg 232 sale of the system decreases. However, every spontaneous or energetically favorable reaction needs to overcome an energy barrier known as the activation energy barrier because of the formation of an u
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br Authors contribution br Disclosure statement br Acknowled
2019-11-05
Authors contribution Disclosure statement Acknowledgements This study has received funding from the Italian Ministry of University and Research (PRIN 2015, grant number 2015373Z39_008) and from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 115797 (INNODIA)
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br Development of the double strand break repair model
2019-11-05
Development of the double strand break repair model for meiotic recombination Meiotic recombination was first described by Frans Alfons Janssens using kanamycin sulfate in the salamander Batracoseps attenuatus in 1909 [21] and then further elaborated at the genetic level in Drosophila by Thomas
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br O GlcNAc transferase OGT belongs
2019-11-05
O-GlcNAc transferase OGT belongs to the metal-independent GT-B superfamily of glycosyltransferases, which has been well-reviewed previously [14,15]. OGT is an essential gene encoded on the X-chromosome, and it has two main regions: a long N-terminal tetratricopeptide repeat (TPR) region and a C-t
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In the phase I AURA trial patients with EGFR activating
2019-11-05
In the phase I AURA trial, patients with EGFR activating mutations and centrally confirmed tumor and/or plasma genotyping (BEAMing) T790M result were enrolled. Among 216 patients with both plasma and tissue genotyping results, the concordance rate was 82% for 87 6 19 deletions, 86% for L858R and 70
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The present work shows that normal climatic
2019-11-05
The present work shows that normal climatic conditions are not critical for the long time survival of DNA in untreated blood stains. This information may be useful for laboratories who wish to store reference blood samples in a simple way, while saving the costs of commercial substrates that are tre
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br Conclusion The present work describes the
2019-11-05
Conclusion The present work describes the synthesis of 18 naphthoquinonolyl-1,2,3-triazole compounds based on natural product modification with antiplasmodial activity. Lapachol derivatives disclosed higher activity than the natural product. Six of these final modified lapachol 1,2,3-triazole com
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The total reduced glutathione content was determined in
2019-11-05
The total reduced glutathione content was determined in both Probenecid to examine whether retinol was decreasing glutathione concentrations and thus decreasing the conjugation of NAPQI. Total hepatic (3.9±0.3 vs 4.9±1.0 μmol/g, retinol vs untreated, respectively) and renal (0.4±0.1 vs 0.2±0.1 μmol
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hcv virus br Cytokine profile in MPN Results from
2019-11-05
Cytokine profile in MPN: Results from experimental investigation Cytokines are small molecules constituted by proteins or glycoproteins, which regulate the immune cell function and the immune system. They are secreted mainly by immune hcv virus but also by other cells such as epithelial cells in
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Agglutinin like sequence ALS gene is
2019-11-05
Agglutinin-like sequence (ALS) gene is well-characterized gene family in candidiasis due to its importance in pathogenicity of C albicans. Previously, C. albicans ALS1 gene product was reported as cell surface protein that mediates adherence to endothelial and epithelial cgrp antagonist in vitro and
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Introduction Cytochrome P CYP A is the
2019-11-05
Introduction Cytochrome P450 (CYP)3A is the most important enzyme involved in the metabolism of 30–40% of currently prescribed drugs [1]. The apoptosis inducer level and activity of CYP3A show large intra- and inter-individual variability, which contributes to unpredictable drug response and toxic
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