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In the present study we firstly confirmed the resistance
2019-06-13
In the present study, we firstly confirmed the resistance of osteosarcoma U2OS prolyl hydroxylase to doxorubicin under hypoxia via inhibiting the drug-induced apoptosis. The hypoxia pre-treatment could significantly ameliorate the viability reduction in U2-os cells which were treated with doxorubic
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To date only one study regarding the role of
2019-06-13
To date, only one study regarding the role of miRNAs during hepatic cyst formation has been published. While this is an older publication, published in 2008, the findings are worth discussing, based on the limited information on miRNAs during PLD. In whole liver sections from patients with PLD due t
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br Hospitals in low income and
2019-06-13
Hospitals in low-income and middle-income countries receive surgical patients late, and usually when they are critically ill. Consequently, high perioperative mortality and poor surgical outcomes are the unacceptable results of the provision of surgical health care in these countries. However, the
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Hereditary syndromes with increased risk
2019-06-12
Hereditary syndromes with increased risk for gastric cancer include: 1) hereditary diffuse gastric cancer, 2) Lynch syndrome/hereditary non-polyposis colorectal cancer, 3) juvenile polyposis syndrome, 4) Peutz-Jeghers syndrome and 5) familial adenomatous polyposis. Hereditary diffuse gastric cancer
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br Since the launch of the Every Newborn Action
2019-06-12
Since the launch of the Every Newborn Action Plan (ENAP) at the World Health Assembly in 2014, and, in 2015, the launch of the UN Secretary General\'s second Global Strategy for Women\'s, Children\'s and Adolescents\' Health, there has been a renewed focus on improving newborn health globally. So
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mitoxantrone We used MRI images taken to
2019-06-12
We used MRI images taken 1 to 8 weeks after a crisis to explore basal ganglion involvement and found restricted mitoxantrone at the basal ganglion. This finding suggests that cytotoxic damage to the basal ganglion persists post-crisis. When MRI images were obtained much longer after crisis, restrict
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Clinical genetic electrocardiographic and electrophysiologic
2019-06-12
Clinical, genetic, electrocardiographic, and electrophysiological variables did not differ significantly between patients with and without the ER pattern (Table 2). Discussion Among our Brugada syndrome patients, the prevalence of the ER pattern was 10.1%, which is high in comparison to the 2%–5
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PPCL were associated with a very
2019-06-12
PPCL were associated with a very poor prognosis. The median survival duration according to published small trials was short, ranging from 7 to 13 months, with less than 10% of patients having a median survival of more than 5 years. In the largest recently published epidemiological study, the median
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br VIII Si atendemos a
2019-06-12
VIII. Si atendemos pim inhibitor que Pablo del Prado en su Directorio espiritual, todavía en el año de 1650, incorporaba numerosas oraciones para la comunión espiritual indígena, junto a recomendaciones sobre la exclusión de la efectiva, no parece probable que se alcanzara nunca una normalización
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br Conclusion br Conflict of interest br
2019-06-11
Conclusion Conflict of interest Introduction Loss-of-function mutations in the cardiac sodium (Na+) channel gene have been implicated in Brugada syndrome, progressive cardiac conduction defect (PCCD), sick sinus syndrome, and idiopathic ventricular fibrillation (IVF) [1]. In the present stu
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In addition to CAF in the primary tumour microenvironment it
2019-06-11
In addition to CAF in the primary tumour microenvironment, it is tempting to speculate that fibroblasts within the bone itself may play a role in the establishment of metastatic deposits. Fibroblasts form a major component of the bone marrow stroma and regulate haematopoiesis by secreting a range of
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Obeticholic Acid br El hispanismo criollo de vasconcelos br
2019-06-11
El hispanismo criollo de vasconcelos Conclusiones: “próspero” vasconcelos Sin la disciplina personal ni el pragmatismo, inculcado por la pequeña escuela texana, Vasconcelos no hubiera logrado todo lo que se propuso desde joven. El peligro de la dispersión y la pereza latinoamericana ya lo habí
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br Material and methods The study subjects
2019-06-11
Material and methods The study subjects were 28 consecutive patients with organic thymidine phosphorylase disease who underwent ICD implantation for the secondary prevention of sudden cardiac death, based on the indications for ICD implantation in the European Society of Cardiology׳s guidelines [
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In this context in Heather Zar
2019-06-11
In this context, in , Heather Zar and colleagues report findings from the first study to assess the accuracy of Xpert MTB/RIF in young children presenting to a primary-care facility with symptoms of pulmonary tuberculosis. Primary analysis was done in 309 children in whom four samples (two induced s
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Detailed data were available in Kilifi not only on
2019-06-11
Detailed data were available in Kilifi not only on carriage of vaccine types of pneumococci, but also on receipt of vaccine by the individuals in the study, and the overall vaccine coverage in the PD 173074 was also known. The data suggest that vaccine coverage of around two-thirds of children youn
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