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This is the first report describing
2019-05-20
This is the first report describing the occurrence of HLH in a patient with refractory CLL who had started Ibrutinib treatment. Hemophagocytic lymphohistiocytosis (HLH) is a rare and frequently fatal disorder characterized by an ineffective T-cell and NK response resulting in an exuberant cytokine p
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br Cholera remains a serious global public health
2019-05-20
Cholera remains a serious global public health problem, disproportionately affecting poor individuals, causing illness and death for thousands of people each year. Cholera cases are on the rise, with 47% more cases reported to WHO in 2014 than in 2013. Innovative approaches to control the disease
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br Risk of bleeding complications
2019-05-20
Risk of bleeding complications with dual antiplatelet agents Dual antiplatelet therapy (DAPT) with combined aspirin and clopidogrel has become a standard treatment after percutaneous coronary intervention (PCI). Recent studies have examined the impact of such therapy on the incidence of bleeding
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With respect to the ST elevation in the precordial lead
2019-05-20
With respect to the ST elevation in the precordial lead, Antzelevitch et al. demonstrated that this can be an reductase enzyme of early repolarization or J-wave caused by transient outward current (Ito)-mediated transmural differences in the early phases of the action potential. BS is an inherited
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Another recent study also concluded that presence of EMD
2019-05-20
Another recent study also concluded that presence of EMD at diagnosis, rather than any treatment modalities ever used, was the only significant predictor of extramedullary recurrence. This finding suggests that the development of EMD, even during treatment, may possibly reflect different tumor biolo
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Numerous animal studies have demonstrated
2019-05-20
Numerous animal studies have demonstrated beyond doubt that effective inhibition of osteoclastogenesis or osteoclast function significantly reduces metastatic tumour growth in bone [13–20]. Likewise, clinical trials in patients with non-metastatic or metastatic cancers established that treatment wit
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The regular meridians are distributed symmetrically on the l
2019-05-18
The 12 regular meridians are distributed symmetrically on the left and right sides of the body, and run along their fixed courses. The temperature of paired bilateral acupoints shows symmetry and correlation to the left and right sides. One member of our research group, Bing Xiong, compared the skin
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br Methods br Results br Discussion
2019-05-18
Methods Results Discussion Conclusions Conflict of interest statement Introduction Pulmonary vein (PV) isolation using a conventional electrode catheter is an effective therapy for atrial fibrillation (AF) [1,2]. However, it requires a long procedure time and has occasionally been
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the later elementary years br Commentary Her ECG showed a re
2019-05-18
Commentary Her ECG showed a regular wide QRS complex tachycardia at a rate of 130 beats per minute. The morphology of the QRS complex exhibited the right BBB (RBBB) pattern with inferior axis. The duration of the QRS complex was 0.16s. P waves of sinus origin were not seen, presumably hidden in t
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The outcome of sinus node modification with radiofrequency
2019-05-18
The outcome of sinus node modification with radiofrequency ablation has been reported, but it involves a high invasive risk associated with the ablation. Thus, careful confirmation of the earliest activation site and ablation of that site is important [2,3]. The clinical use of the 3D-mapping system
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cyp450 inhibitors Poor knowledge among caretakers of how to
2019-05-18
Poor knowledge among caretakers of how to work with disability-related disorders could also be an issue. For example, poor knowledge of how to correctly position a child with severe cerebral palsy could lead to inadequate feeding; at worst, these efforts can cause aspiration and even death. Social a
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Pero todo cambia despu s del exilio en Francia son
2019-05-18
Pero todo cambia después del exilio en Francia; son los presuntos “bárbaros” los únicos que parecen ser capaces de una auténtica revolución: dirá Bilbao con admiración que ellos fueron los que en 1848 hicieron Tariquidar las “naciones de Europa […] estremecerse como bajo las plantas de Attila”. Los
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Obesity with excessive fat was an important risk
2019-05-17
Obesity with excessive fat was an important risk factor for the occurrence or progression of cardiac arrhythmia. As compared to abdominal fat, the amount of epicardial fat more correlates with the occurrences of atrial fibrillation, which suggests the distinctive arrhythmogenic effects of epicardial
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br Anticoagulation reversal Anticoagulation may require elec
2019-05-17
Anticoagulation reversal Anticoagulation may require elective (as described above) or emergent reversal. Vitamin K may be administered, which substantially reduces INR within 24h; the rapidity of INR decrease depends on the route of administration and the dose [51,52]. Oral administration is pref
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The excellent birth cohort study reported in
2019-05-17
The excellent birth cohort study reported in by Heather Zar and colleagues, done in a periurban area outside Cape Town in South Africa, is a good example of a study that has provided important information about child pneumonia at a time of change. It provides the first incidence estimates of pneumo
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