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focal adhesion kinase PPCL were associated with a
2019-04-26
PPCL were associated with a very poor prognosis. The median survival duration according to published small trials was short, ranging from 7 to 13 months, with less than 10% of patients having a median survival of more than 5 years. In the largest recently published epidemiological study, the median
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br Approval statement br Role of the funding source
2019-04-26
Approval statement Role of the funding source Conflict of interest Acknowledgments Introduction Osteosarcoma (OS) is the most common malignancy of bone, mainly affecting children, adolescents and young adults. According to the American Cancer Society, 750–900 new cases of OS are diagn
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Cell adhesion to extracellular matrix requires the interacti
2019-04-26
Cell adhesion to extracellular matrix requires the interaction of different molecules like selectins, cadherins and integrins [21]. Especially αvβ3 integrin has been proposed to mediate the adhesion of malignant cells in different entities such as multiple myeloma and breast cancer [22,23]. Upon exp
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br Materials and methods A retrospective questionnaire surve
2019-04-26
Materials and methods A retrospective questionnaire survey was conducted among 299 JHRS institutions from December 2012 to January 2013. Patients with persistent AF who underwent TEE for elective ECV were included. LA thrombus incidence, risk factors for thrombus formation as indicated by the CHA
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We built and improved on
2019-04-26
We built and improved on previous models of research capacity strengthening and used an integrated approach not only focused on individual researchers or providing technical assistance but also on fostering an institutional environment that GSK2126458 is supportive of safe and ethical science. Our m
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In Fatima Mir and colleagues
2019-04-26
In , Fatima Mir and colleagues report results from the Simplified Antibiotic Therapy Trial (SATT) in Pakistan, in which three antibiotic regimens were compared for treatment of neonatal infections: procaine benzylpenicillin and gentamicin; amoxicillin and gentamicin; and procaine benzylpenicillin, g
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Finally we have a means of monitoring
2019-04-26
Finally, we have a means of monitoring pace–sense conductor failure in an ICD lead. LIA™ (Lead Integrity Alert, Medtronic, Minneapolis, MN, USA) is a detection system for ICD pace–sense conductor failure [16]. Remote monitoring is also effective using this method of lead failure detection [17]. Howe
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Another widely used tool is the Brief Pain Inventory BPI
2019-04-25
Another widely used tool is the Brief Pain Inventory (BPI), developed by Cleeland and Ryan. The BPI is a questionnaire used to determine overall pain intensity and functional interference as a result of pain. Specifically, it bet inhibitor examines functional interference in terms of general activi
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br Authorship br Conflict of interest disclosure br Introduc
2019-04-25
Authorship Conflict of interest disclosure Introduction The Aurora kinases are serine/threonine protein kinases essential for regulation of normal Anti-diabetic Compound Library mitosis. Aurora kinases A (AAK) and B are overexpressed in hematologic malignancies, including acute myeloid leu
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br Signal averaged electrocardiography SAECG SAECG is
2019-04-25
Signal-averaged electrocardiography (SAECG) SAECG is a high-resolution electrocardiographic technique developed in the 1970s for detecting patients who are prone to SCD after MI. It is based on the theory that lethal ventricular arrhythmias leading to SCD often have a reentrant mechanism. Reentry
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Amiodarone has been used in Japan for more than
2019-04-25
Amiodarone has been used in Japan for more than 5 years now since its approval in July 2007, and intravenous amiodarone has been widely used for life-threatening ventricular tachycardia in the setting of critical care medicine. However, only few reports have been published in the international liter
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br Other candidate genes br The frequency of
2019-04-25
Other candidate genes The frequency of minor gene mutations in BrS As mentioned above, more than 10 genes have been reported to cause BrS. The proportions of BrS patients who are mutation carriers, however, are very small, except in the case of SCN5A. In a recent extensive mutation analysis of
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br Treatment and follow up recommendations for patients
2019-04-25
Treatment and follow-up recommendations for patients receiving aromatase inhibitors Conclusions and future directions It is evident that, in addition to BMD, clinical risk factors can greatly influence fracture risk. In addition to morbidity and mortality, fractures are associated with high he
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br Conclusion br Funding br Conflict of interest br
2019-04-25
Conclusion Funding Conflict of interest Acknowledgments Introduction Ventricular tachyarrhythmias (VTs) are life-threatening events that result in hemodynamic compromise; therefore, patients often require immediate treatment such as electrical cardioversion. Despite appropriate manage
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mg to mol Remote monitoring offers ongoing opportunities for
2019-04-24
Remote monitoring offers ongoing opportunities for management from three perspectives: Concept of remote monitoring for mg to mol failure Most HF-related hospitalizations are due to fluid accumulation, and careful surveillance of a patient\'s fluid status and symptoms is important [20]. To effec
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