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Roughly years have gone by
2019-04-20
Roughly 15 years have gone by since the identification of the main characters involved in the interplay of the RANK–RANKL system. This gave rise to the race for elucidating their biological role . In those years, in vivo silencing experiments for both Receptor Activator of Nuclear Factor κ B (RANK)
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Introduction Bone metastases are a common manifestation of c
2019-04-20
Introduction Bone metastases are a common manifestation of cancer [1]. Most patients present with pain and impaired mobility, while others can develop complications such as pathological fractures and mpges-1 inhibitors of the spinal cord or cauda equina [2]. Many randomized studies have been condu
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Certainly dynamic interactions between DTCs and stromal cell
2019-04-20
Certainly, dynamic interactions between DTCs and stromal gpr44 inhibitor within the bone microenvironment disrupt bone homeostasis, which is normally tightly controlled, to fuel metastatic progression [18] (Table 1). For example, it is well established that osteolytic breast cancer DTC-derived facto
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Por otro lado cabe subrayar que esta eleg a de
2019-04-20
Por otro lado, cabe subrayar que esta “elegía” de Pellicer se asemeja al género precolombino del icnocuicatl, los “Canto[s] de desolación, de orfandad” (Garibay 1992: 89). Según Garibay, estos cantos precolombinos “tienen parentesco con las elegías […] de los poetas de Occidente, en que se canta la
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Aunque m s por afinidad electiva que por
2019-04-20
Aunque más por afinidad electiva que por propia decisión del autor, lo cierto es que justamente ese conjunto de rasgos aproximaría la obra al llamado libro de artista, modalidad creativa tan característicamente vanguardista como la simulación crítica, la interdisciplinariedad, el collage, el disposi
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De acuerdo con los planteamientos anteriores pensemos en la
2019-04-20
De acuerdo con los planteamientos anteriores pensemos en la propuesta que se obtendría desde la obra de Villoro respecto cgrp antagonist la situación política para un miembro perteneciente a una comunidad indígena, en tanto que además de pertenecer a ella se reconozca como ciudadano del Estado-nació
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El n mero de ofrece
2019-04-20
El número 62 de ofrece, en una primera sección, tres artículos que se ubican en los campos de la literatura, las revistas culturales y en general las redes intelectuales en América Latina. Lucía Di Salvo León y Patricio Herrera González, en “¿Una poética del exilio? La revista y el exilio republica
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Methods We extracted data from the WHO Health
2019-04-20
Methods We extracted data from the WHO Health Expenditure Observatory and the Institute for Health Metrics and Evaluation\'s Financing Global Health 2015 report. We then adjusted these data by converting to a common, inflation-adjusted currency, and completed the series using multiple imputation. We
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br In an age when everything from sparrows to
2019-04-20
In an age when everything from sparrows to toilets has its own international day (March 20 and November 19, respectively, in case you were wondering), it\'s perhaps no surprise that the scholarly publishing glp-2 has got in on the act. This week is . Organised by representatives from publishers,
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HSP plays a crucial role as a main
2019-04-19
HSP90 plays a crucial role as a main molecular chaperone in the regulation of proteostasis such as protein refolding under stress conditions [30]. It has been established that HSP90 binds a client protein such as Raf-1 and forms more continuous and stable functional complex [29]. On the other hand,
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br A KCNJ mutation corresponding to an
2019-04-19
A KCNJ8 mutation, corresponding to an S422L mutation in the protein, was first identified in a 14-year-old girl with early repolarization [59], who suffered frequent VF attacks. KCNJ8 encodes Kir6.1, which has 2 transmembrane regions, and the KATP channel is composed of a complex of Kir6.1 or Kir6
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Lead failures are classified as either structural lead failu
2019-04-19
Lead failures are classified as either structural lead failures or electrical lead failures, and failures of 8F single coil leads are more frequently reported. Structural failures occur with a reported incidence of 14–34% and are evident as cable exteriorization in fluoroscopy studies [6,7]. Electri
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The miR signature of exosomes isolated
2019-04-19
The miR signature of exosomes isolated from bulk prostate cancer crf hormone (Fig. 1A, blue cells) and from their cancer stem cell compartment (Fig. 1A, green cells), display high levels of miR-21, miR-30 and miR-218 [23] (Fig. 1A, blue arrow). miR-21 and miR-30 have been identified as key regulato
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br Conclusions br Disclosures br Funding Sources
2019-04-19
Conclusions Disclosures Funding Sources Introduction Pulmonary vein isolation (PVI) has become an accepted treatment for atrial fibrillation (AF) [1]. The efficacy of PVI is sometimes insufficient, and atrial substrate modification of target specific AF signals indicating the substrate r
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A number of clinical studies have confirmed the beneficial e
2019-04-19
A number of clinical studies have confirmed the beneficial effect of ranolazine in either prevention or treatment of AF. The first strong evidence was provided by MERLIN-TIMI 36 trial [the Metabolic Efficiency With Ranolazine for Less Ischemia in Non–ST-Elevation Acute Coronary Syndrome–Thrombolysis
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