• Several mechanisms are implicated in lipid

  2019-09-10

  

  Several mechanisms are implicated in lipid-induced insulin resistance in muscle, including oxidative stress (Koves et al., 2008, Zhang et al., 2011, Muoio and Neufer, 2012). Mitochondrion is a major source of ROS production. The oxidation of pyruvate and fatty protease inhibitors yielding acetyl-Co

• We and others have previously found that supplementation of

  2019-09-10

  

  We and others have previously found that supplementation of old rats with ALCAR remediates the age-related decay in mitochondrial bioenergetics in liver (Hagen et al., 1998a, Hagen et al., 1998b), heart (Paradies et al., 1994, Paradies et al., 1999), muscle (Pesce et al., 2010) and 78 7 kinase (Liu

• Allele specific methylation has been observed in

  2019-09-10

  

  Allele-specific methylation has been observed in CpG islands of imprinted genes.27, 32 In the present study, however, methylation of CpG1 was specific to ALL neuraminidase inhibitors and occurred in the leukemia cells of 28% of children with ALL, but it was not found in normal leukocytes from the s

• The small intestine is the only organ responsible for

  2019-09-10

  

  The small intestine is the only organ responsible for the Fludara of dietary and biliary cholesterol, leaving the unabsorbed cholesterol to be excreted in feces and together contributing to the body cholesterol homeostasis [13], [21], [33], [34]. Following intraluminal hydrolysis, free cholesterol

• Berner et al used a meta analysis to show

  2019-09-10

  

  Berner et al used a meta-analysis to show that sildenafil resulted in an effect of 9.65-point improvement. Tadalafil could be pooled into an effect of 8.52-point improvement, and vardenafil showed an effect of 7.50-point improvement. In our present studies, 200 mg udenafil resulted in an effect of 8

• br The modulation of ER from SERMs to

  2019-09-10

  

  The modulation of ERα: from SERMs to TSECs Continued efforts to provide women with efficacious menopausal therapies have generated interest in the development of selective Nifedipine clinical receptor modulators (SERMs). Similar to estrogens, SERMs have been shown to bind to ERs with high affini

• In our former work our interest

  2019-09-10

  

  In our former work, our interest was in discovery of novel VEGFR-2 inhibitors as anti-angiogenesis agents. Along this line, with natural alkaloid taspine as the lead compound, rounds of structure optimization were performed to develop novel VEGFR-2 inhibitors [[13], [14], [15]]. Among them, BPS-7, b

• We not only found that the ISR leads

  2019-09-10

  

  We not only found that the ISR leads to attenuation of conventional cap-dependent translation with no change in RAN translation of the G4C2 expanded repeat, but also that GA translation from the expanded repeat (but not from 5 G4C2 repeats, perhaps because the protein product does not aggregate) is

• Most of the data indicating that the six

  2019-09-10

  

  Most of the data indicating that the six-ankyrin repeat domain-containing Asb genes drive compartment expansion come from zebrafish and concern Asb11. However, there is evidence to suggest that these data can be expanded to the entire vertebrate phylum and to all six-ankyrin repeat domain-containing

• E is a classical initiator protein and as such

  2019-09-10

  

  E1 is a classical initiator protein and, as such, plays several roles in the initiation and catalysis of viral DNA synthesis. E1 must first recognize a specific segment of the viral k145 known as the “origin of DNA replication”, or “ori” for short. For most PV types examined to date, the minimal or

• EP EP and EP receptor

  2019-09-09

  

  EP1, EP3 and EP4 receptor expression on HMVEC-L was shown recently by flow cytometry [14]. However, only EP4 mRNA expression was previously described in these cells [49]. Our data obtained with RT-PCR showed EP4 mRNA and very low levels of EP1 mRNA, but no EP2 and EP3 mRNA expression was detectable

• br Discussion Immune response to CMV is a series

  2019-09-09

  

  Discussion Immune response to CMV is a series cell-mediated immune response initiated by innate innate NK cells, followed by adaptive CD8+ and CD4+ T cells and humoral immunity by B cell [3]. Prior to transplant, measurement of humoral immune responses (CMV serology) of donor and recipient is com

• closantel and During ischemia the impact of CK on mitochondr

  2019-09-09

  

  During ischemia, the impact of CK2 on mitochondria varies in different organs/tissues. For example, CK2α upregulation during ischemia leads to disrupted mitochondrial homeostasis and mediates cardiomyocyte ischemic injury [31]. Specifically, ischemia/reperfusion (I/R) progressively increases CK2α to

• Next to organophosphates carbamates and metals cholinesteras

  2019-09-09

  

  Next to organophosphates, carbamates and metals, cholinesterase activity can also be affected by other pesticides, such as newer generation neonicotinoid insecticides (NN). NNs do not inhibit AChE activity via the organophosphate-sensitive binding site of the enzyme, but rather, by acting as a struc

• Raloxifene is a second generation SERM that has tissue speci

  2019-09-09

  

  Raloxifene is a second generation SERM that has tissue-specific effects that differ from those of tamoxifen. Raloxifene was marketed for prevention and treatment of osteoporosis in postmenopausal women in the US and Europe. In a phase II randomized double-blind study, tamoxifen and raloxifene were e

16330 records 987/1089 page Previous Next First page 上5页 986987988989990 下5页 Last page