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Duchenne muscular dystrophy DMD is a recessive X linked
2018-11-09
Duchenne muscular dystrophy (DMD) is a recessive X-linked form of genetic muscle disease affecting approximately 1 in 3500 males (). Boys with DMD carry mutations in the dystrophin gene resulting in defective or absent dystrophin protein. Both skeletal and cardiac muscles undergo progressive damage
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alkylation of dna Exactly when and how HCV activates the PHB
2018-11-09
Exactly when and how HCV activates the PHBs-mediated signaling remains to be investigated. PHB1/2 do not precipitate with CD81, SR-BI, CLDN1, or OCLN, but are associated with HCV E2 in both infected and co-transfected cells. PHBs are anchored to the plasma membrane or mitochondrial inner membrane by
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Introduction Mesenchymal stem cells MSCs are
2018-11-08
Introduction Mesenchymal stem cells (MSCs) are believed to be the source of osteoblastic cells during normal bone growth and remodeling and may be isolated from the bone marrow, among other tissues. Mesenchymal stem cells are a sub-population of bone marrow-derived cells characterized by their abil
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br Conclusions The following are
2018-11-08
Conclusions The following are the supplementary data related to this article. Acknowledgments We thank Drs. Tomoki Todo and Nobuhito Saito of the University of Tokyo, Japan, for generously providing us with the TGS01 cells. This work was supported by Grants-in-Aid for Scientific Research, for
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Many studies have demonstrated that
2018-11-08
Many studies have demonstrated that GSCs isolated from glioblastomas display a capacity for multiple-lineage differentiation (Hemmati et al., 2003; Matsuda et al., 2012; Singh et al., 2003, 2004; Sunayama et al., 2010b). When differentiated, these Caspase-1, mouse recombinant protein usually lose t
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Differentiation of HD ESCs had only a minor
2018-11-08
Differentiation of HD ESCs had only a minor effect on repeat expansion; this was as expected considering the low level of somatic expansion found in most tissues. We did, however, find that differentiation status influenced the effect introduced oxidative DNA damage had on CAG expansion. Mouse model
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Attempts to expand olfactory stem cells
2018-11-08
Attempts to expand olfactory stem ketotifen fumarate according to the free-floating cell aggregate central nervous system (CNS) neurosphere culture method (Reynolds and Weiss, 1992) have been described (Barraud et al., 2007; Sicard et al., 1998; Carter et al., 2004). Olfactory spheres (OSs), cluster
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Vacuolar ATPases V ATPases are large
2018-11-08
Vacuolar ATPases (V-ATPases) are large multi-subunit complexes that are organized into V0 and V1 domains, which operate by a rotary mechanism (Forgac, 2007). V-ATPase-driven proton pumping and organellar acidification are essential for vesicular trafficking along both the exocytotic and endocytotic
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JSH-23 Pluripotent stem cells exhibit characteristic interac
2018-11-08
Pluripotent stem JSH-23 exhibit characteristic interactive protein–protein networks during self-renewal and differentiation. Quantitative mass spectrometry analysis showed that during differentiation, 1399 proteins are phosphorylated on 3067 residues (Van Hoof et al., 2009). These data might provide
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order withaferin a Several lines of evidence suggest that mi
2018-11-08
Several lines of evidence suggest that mitochondrial insufficiency and failure to leave glycolysis (Warburg metabolism) are the fundamental limits to normal differentiation after FGF4 removal. These lines of evidence also pinpoint the two lineages at the labyrinthine surface as the highest energy- a
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The present results found that
2018-11-08
The present results found that under osteogenic induction, hydrostatic pressure promoted the belongs to of marker genes for early osteogenic differentiation in BMSCs through the activation of RhoA/ROCK. It was reported that the activated RhoA/ROCK proteins enhanced myosin motor activity through an i
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br Methods and materials br Results br Discussion Existing m
2018-11-08
Methods and materials Results Discussion Existing methods for hPSC differentiation to endothelial progenitors require the addition of growth factors and/or xenogenic components, limiting their application for large-scale production and therapeutic applications (Bautch, 2011; Wilson et al.,
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The finding that MHC and myogenin expression does not change
2018-11-08
The finding that MHC and myogenin expression does not change upon ectopic Msx1 expression but decreases drastically upon Msx2 expression is another piece of evidence for the selective role of MSX2 in dedifferentiation. The previous two studies on MSX1 induction in myotubes did not characterize MHC l
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The occurrence of airway epithelial thickening
2018-11-08
The occurrence of airway epithelial thickening in topoisomerase inhibitors leads to a decrease in airway lumen size, consequently resulting in increased airway resistance corresponding to AHR (Elias, Zhu, Chupp, and Homer, 1999). Data from pediatric and non-fatal asthma studies have shown epithelial
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br Resource table Resource details RCe A RC was derived
2018-11-08
Resource table. Resource details RCe008-A (RC-4) was derived from a fresh am580 that was surplus to requirement or unsuitable for clinical use. The cell line was derived by whole embryo outgrowth on a chemically defined matrix consisting of laminin, fibronectin, Collagen IV and vitronectin (Lud
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