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Having confirmed that the Nanog
2018-11-06
Having confirmed that the Nanog−/− iPSCs expressed key markers of pluripotency, we sought to determine the extent to which the global expression profile of Nanog−/− iPSCs recapitulated that of ESCs. To this end, we performed RNA sequencing (RNA-seq) of two replicates each of control Nanog+/+ ESC, iP
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The recovery of ExEn outer layer and
2018-11-06
The recovery of ExEn outer layer and down-regulation of pluripotent genes in mutant EBs grown in medium supplemented with BMP4 indicate that the failure of Pelo-null cells to down-regulate pluripotency-related genes in EBs is not a result of cell-autonomous effect, but rather to failed signals from
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br Lineage tracing tools for
2018-11-06
Lineage tracing tools for investigating stem cell biology The investigation of cell lineage involves labeling 1-Deoxynojirimycin of interest, then tracing the destiny of their progeny. The reliance on the presence of cell markers alone to infer the origin or fate of a cell population is fallible,
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The chronotropic responses of the hPSC CMs to various cardio
2018-11-06
The chronotropic responses of the hPSC-CMs to various cardio-active drugs in our study are well in line with the published results (Mandel et al., 2012; Pillekamp et al., 2009; Pillekamp et al., 2012; Xu et al., 2002), in which the beating rates of CMs were increased in response to isoproterenol and
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Based on our findings on genome wide epigenetic effects of
2018-11-06
Based on our findings on genome-wide, epigenetic effects of EtOH on DPSCs, we analyzed known epigenetic modifiers to elucidate a potential epigenetic link between alcohol and osteoporosis. Consistent with our conclusion, KDM6B, a known epigenetic modifier involved in osteogenic and odontogenic diffe
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Also critical to the success of hard tissue engineering stra
2018-11-06
Also critical to the success of hard tissue engineering strategies is the selection and use of an appropriate growth factor regimen. Although several growth factors are reported to play an important role in the process of matrix mineralisation, IGF-1 is the most abundant growth factor in bone matrix
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br Introduction Neuron regeneration in adult mammalian brain
2018-11-05
Introduction Neuron regeneration in adult mammalian bcr-abl tyrosine kinase inhibitors is important for alleviation of brain injuries or neurodegenerative diseases. As the regeneration capacity of adult brains is limited (Goldman, 2016), cell replacement therapy using exogenous cells seems promi
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Source address field is the
2018-11-05
Source address field is the sender\'s address of 2 octets, in accordance with the value of the source addressing mode subfield in the frame control field and determines the address of the frame source. This field is included in the MAC-frame if the source addressing mode subfield is not equal to zer
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should be satisfied over the entire domain of the
2018-11-05
should be satisfied over the entire domain of the functions (7). Fig. 3 shows plots of the – (3) functions for the GPU. Eq. (5), unlike the others, does not satisfy the monotonicity requirement. Eq. (3) is simpler but less accurate. Eq. (4) is more complicated to ensure monotonicity but for Eq. (6)
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br Declaration of Interests br Authorship br
2018-11-05
Declaration of Interests Authorship Acknowledgments Introduction The main clinical problems of people living with HIV (PLWH) in areas with adequate healthcare standards and continued antiretroviral therapy (ART) supply are increasingly related to premature aging (Paiardini and Müller-Tru
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order l-ascorbic acid Given the phase trial results we sough
2018-11-05
Given the phase 1 trial results, we sought to address a complementary question whether VIS410 could be successfully deployed in the event of an epidemic outbreak to improve public health outcomes. We predicted that given VIS410\'s half-life, its distribution to the primary site of influenza A infect
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An important implication of our results
2018-11-05
An important implication of our results is that they point to the correct ‘scale’ of analysis that addresses the possibility of H 89 in FSE-L and malfunction in FSE-NL. The results best represent the ‘meso-scale’ level of analysis between physiological alterations due to FSE and observable differenc
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br Materials and Methods br Results
2018-11-05
Materials and Methods Results Discussion The thoracic aortic aneurysm in BAV patients frequently involves ascending aorta, where the SMCs are derived from the neural crest. In contrast, patients with BAV rarely have aneurysms involving the descending thoracic aorta, and the SMCs in this reg
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Sample collection for a cohort is often
2018-11-05
Sample collection for a cohort is often carried out at the time of diagnosis, time of treatment or time of screening of healthy individuals, and not confined to a certain time of the year. This implies that environmental factors, such as pollen concentration in the spring, may cause downstream effec
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Consistent with the phenotypic response to ANXA
2018-11-05
Consistent with the phenotypic response to ANXA suppression (Fig. 6), suppression of ANXA2 led to an alteration of not only mesenchymal signatures but also cell cycle related pathways, such as cell cycle checkpoint genes (Gene Set Enrichment Analysis p=8.6×10, q=8.6×10, Supp Table 1). Intriguingly,
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