• br Conclusions The following are

  2018-11-08

  

  Conclusions The following are the supplementary data related to this article. Acknowledgments We thank Drs. Tomoki Todo and Nobuhito Saito of the University of Tokyo, Japan, for generously providing us with the TGS01 cells. This work was supported by Grants-in-Aid for Scientific Research, for

• Differentiation of HD ESCs had only a minor

  2018-11-08

  

  Differentiation of HD ESCs had only a minor effect on repeat expansion; this was as expected considering the low level of somatic expansion found in most tissues. We did, however, find that differentiation status influenced the effect introduced oxidative DNA damage had on CAG expansion. Mouse model

• Attempts to expand olfactory stem cells

  2018-11-08

  

  Attempts to expand olfactory stem ketotifen fumarate according to the free-floating cell aggregate central nervous system (CNS) neurosphere culture method (Reynolds and Weiss, 1992) have been described (Barraud et al., 2007; Sicard et al., 1998; Carter et al., 2004). Olfactory spheres (OSs), cluster

• Vacuolar ATPases V ATPases are large

  2018-11-08

  

  Vacuolar ATPases (V-ATPases) are large multi-subunit complexes that are organized into V0 and V1 domains, which operate by a rotary mechanism (Forgac, 2007). V-ATPase-driven proton pumping and organellar acidification are essential for vesicular trafficking along both the exocytotic and endocytotic

• JSH-23 Pluripotent stem cells exhibit characteristic interac

  2018-11-08

  

  Pluripotent stem JSH-23 exhibit characteristic interactive protein–protein networks during self-renewal and differentiation. Quantitative mass spectrometry analysis showed that during differentiation, 1399 proteins are phosphorylated on 3067 residues (Van Hoof et al., 2009). These data might provide

• order withaferin a Several lines of evidence suggest that mi

  2018-11-08

  

  Several lines of evidence suggest that mitochondrial insufficiency and failure to leave glycolysis (Warburg metabolism) are the fundamental limits to normal differentiation after FGF4 removal. These lines of evidence also pinpoint the two lineages at the labyrinthine surface as the highest energy- a

• The present results found that

  2018-11-08

  

  The present results found that under osteogenic induction, hydrostatic pressure promoted the belongs to of marker genes for early osteogenic differentiation in BMSCs through the activation of RhoA/ROCK. It was reported that the activated RhoA/ROCK proteins enhanced myosin motor activity through an i

• br Methods and materials br Results br Discussion Existing m

  2018-11-08

  

  Methods and materials Results Discussion Existing methods for hPSC differentiation to endothelial progenitors require the addition of growth factors and/or xenogenic components, limiting their application for large-scale production and therapeutic applications (Bautch, 2011; Wilson et al.,

• The finding that MHC and myogenin expression does not change

  2018-11-08

  

  The finding that MHC and myogenin expression does not change upon ectopic Msx1 expression but decreases drastically upon Msx2 expression is another piece of evidence for the selective role of MSX2 in dedifferentiation. The previous two studies on MSX1 induction in myotubes did not characterize MHC l

• The occurrence of airway epithelial thickening

  2018-11-08

  

  The occurrence of airway epithelial thickening in topoisomerase inhibitors leads to a decrease in airway lumen size, consequently resulting in increased airway resistance corresponding to AHR (Elias, Zhu, Chupp, and Homer, 1999). Data from pediatric and non-fatal asthma studies have shown epithelial

• br Resource table Resource details RCe A RC was derived

  2018-11-08

  

  Resource table. Resource details RCe008-A (RC-4) was derived from a fresh am580 that was surplus to requirement or unsuitable for clinical use. The cell line was derived by whole embryo outgrowth on a chemically defined matrix consisting of laminin, fibronectin, Collagen IV and vitronectin (Lud

• br Material methods br Results br

  2018-11-08

  

  Material & methods Results Discussion Acknowledgements We thank Melissa Carballosa-Gautam in the Miami Project to Cure Paralysis Imaging Core. This design, experimentation, data analysis and manuscript writing was supported by the Miami Project to Cure Paralysis; NIH/NINDS (DJL: NS049545

• br Materials and methods br

  2018-11-08

  

  Materials and methods Author disclosure statement Acknowledgments This study was supported by fund from National Medical Research Council (NMRC) of Singapore, the Translational Clinical Research (TCR) award (NMRC/TCR/013-NNI/2014) and STaR award (NMRC/STaR/014/2013). We thank Ms. Fiona Seti

• br Results br Discussion Depression

  2018-11-08

  

  Results Discussion Depression is one of the most common and serious side effects of IFN, which can limit its success as an antiviral or antitumor therapy. In this study, we used a simple depression model with definitive molecular targets, IFN-α and IFNAR. Rodents treated with mIFN-α were repor

• The derivation of human induced pluripotent

  2018-11-08

  

  The derivation of human induced pluripotent stem cyp450 inducers (hiPSCs) from fibroblasts (Takahashi et al., 2007) offers new opportunities to study XCI in human cells. For mouse fibroblasts, it has been shown that the Xi becomes reactivated during the reprogramming process, followed by random XCI

16399 records 1075/1094 page Previous Next First page 上5页 10711072107310741075 下5页 Last page