• br Author contributions br Financial disclosures br

  2025-02-07

  

  Author contributions Financial disclosures Acknowledgements We thank Ms. Eva So for the editorial assistance. This work was supported by grants from the National Natural Science Foundation of China (No. 81622015, 81571042 and 81501143) and the National Basic Research Program of China (No. 2

• Another important finding of our

  2025-02-07

  

  Another important finding of our study is the observation that high glucose per se does not affect TER in mature HREC monolayers; but at the same time it does upregulate ICAM-1 directly and activates HRECs to leukocyte adhesion. This would imply that high glucose affects TER in mature HREC monolayer

• WIN 64338 hydrochloride receptor Within the thrombus there i

  2025-02-07

  

  Within the thrombus, there is heterogeneity in the activation of WIN 64338 hydrochloride receptor based on the concentration gradients of soluble agonists emanating from the site of vascular injury, which has been excellently reviewed by Tomaiuolo et al.[1]. As part of the coagulation cascade, acti

• br Methods br Results br Discussion Adiponectin is

  2025-02-06

  

  Methods Results Discussion Adiponectin is naturally expressed and secreted exclusively from adipocytes, and adiponectin levels and its isoforms in circulation have recently been reported to highly associate with human coronary artery disease (CAD) [46], [47], [48], [49], these studies clear

• The present study showed for the first

  2025-02-06

  

  The present study showed, for the first time, that hirsutine, hirsuteine, rhynchophylline, isorhynchophylline, corynoxeine, and isocorynoxeine in yokukansan can inhibit the 5-HT3 receptor current. These data indicate that part of the effect of yokukansan against the behavioral and psychological symp

• br Materials and methods br Results br Discussions Diabetes

  2025-02-06

  

  Materials and methods Results Discussions Diabetes is mainly divided into Type 1 diabetes and Type 2 diabetes [16]. Type 2 diabetes, featured by insulin resistance, results from environmental factors and poor eating habits [2]. Type 2 diabetes accounts for more than 95% of the diabetic pati

• Although ASD is considered one of the most

  2025-02-06

  

  Although ASD is considered one of the most heritable neurodevelopmental disorders (El-Fishawy & State, 2010; Geschwind, 2011) and majority of the research on ASD has focused on the genetics of the disorders (Autism Genome Project, C, 2007; Buxbaum & Hof, 2011), single causative gene anomalies accoun

• br Actin at presynapses br Conclusion Thanks to the

  2025-02-06

  

  Actin at presynapses Conclusion Thanks to the recent discovery of rings, hotspots and trails, axonal carboxypeptidase a is back in the spotlight. These are exiting times for neuronal cell biologists armed with constantly improving labeling and imaging techniques to observe, quantify and pertu

• br Conflicts of interest br Acknowledgments br Significance

  2025-02-06

  

  Conflicts of interest Acknowledgments Significance Introduction Androgen receptor (AR) plays a paramount role in the onset and progression of prostate cancer (PC) (Burnstein, 2005, Lonergan and Tindall, 2011, Watson et al., 2015). This very facet underlies androgen deprivation therapy (A

• As also found by Stolarski et

  2025-02-06

  

  As also found by Stolarski et al. [14], inclusion of N2O in the model is successful in reducing the effect of dynamics [13] in the lower stratosphere in the Northern Hemisphere (30–60°N in our case). The inclusion of N2O also decreased the error bars on the trend values, but the trend values still c

• Epigenetic screening library br Dihydrotestosterone in adult

  2025-02-06

  

  Dihydrotestosterone in adult fish and frogs New perspectives and next directions Similar to other androgens, DHT can modulate reproductive endpoints in both fish and amphibians. However, predicting the effects of DHT can be challenging, as reproductive homeostasis is dependent upon the balance

• br Materials and methods br

  2025-02-06

  

  Materials and methods Results Discussion Author contributions JH purified protein, performed vanadate inhibition experiments, crystallized, collected data, determined and refined the ATX-VO5 structure, analysed all the structures, prepared the displayed items and supervised ALHE; WJK con

• RK-33 Here we investigate the ATM to ATR switch in

  2025-02-06

  

  Here, we investigate the ATM to ATR switch in normal human fibroblasts (82-6 cells) after irradiation with γ-rays, or high LET 56Fe and 28Si and moderate LET 16O particles. Our data provide important evidence of LET dependence on the transition of ATM to ATR as well as end resection at the sites of

• Our research is the first to report

  2025-02-06

  

  Our research is the first to report that administration of HMW-HA is an effective strategy to defend against PM2.5-induced disruption of pulmonary epithelial barrier and lung injury, and addresses that HMW-HA restricts PM2.5-induced epithelial apoptosis through reducing oxidative stress and followin

• br Conclusions In summary aromatase mRNA expression in

  2025-02-06

  

  Conclusions In summary, aromatase mRNA expression in the Vomiting control of A. leptorhynchus shows a similar distribution pattern as seen in other teleosts with expression detected in the forebrain and the pituitary gland. The lack of aromatase mRNA expression in the midbrain and hindbrain of A

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