• Due to its unique histological

  2024-05-10

  

  Due to its unique histological architecture and blood supply, the lung is one of the most susceptible organs under uncontrolled systemic inflammatory circumstance [16]. Several studies have reported the anti-inflammatory benefits of metformin in acute lung injury induced by lipopolysaccharide (LPS),

• br STAR Methods br AMPK

  2024-05-10

  

  STAR★Methods AMPK: A Therapeutic Target in the β Cell? Loss of pancreatic β cell function is a hallmark of the transition to a diagnosis of T2DM (see Glossary) 1, 2, 3, 4. AMPK activation has gained attention for the treatment of hyperglycemia in prediabetes as an insulin-sensitizing agent bec

• and LO are members of the lipoxygenase family that

  2024-05-10

  

  5- and 12/15-LO are members of the lipoxygenase family that convert arachidonic CHAPS receptor into lipid mediators such as leukotriene B4 (LTB) and 12()-hydroxyeicosatetraenoic acid (HETE) and 15()-HETE, respectively. Evidence from several in vitro and in vivo studies has shown that activation of

• br Aldehyde sensors to monitor substrate levels Previous eff

  2024-05-10

  

  Aldehyde sensors to monitor substrate levels Previous efforts to ameliorate metabolic diseases frequently relied on biochemical methods which could measure the levels of toxic substrates in GSK2606414 or bodily fluids (blood and serum or plasma, urine, cerebrospinal fluid). Therapeutic efforts to

• In summary the different types of interstitial cells found

  2024-05-09

  

  In summary, the different types of interstitial cells found in the current study are illustrated in Fig. 7A (see legend for further details), which is suggestive of a heterogeneous complex network of interstitial cells communicating with each other. The possible signaling pathways involving this int

• Introduction Epinephrine is an endocrine hormone mainly prod

  2024-05-09

  

  Introduction Epinephrine is an endocrine hormone mainly produced by adrenal medulla in response to stress (Tank and Lee Wong, 2015). This catecholamine exerts various major physiological effects, concerning notably the cardiovascular system, the respiratory system and the endocrine system, through

• Ambient levels of ppm ozone were recorded during a

  2024-05-09

  

  Ambient levels of 0.2ppm ozone were recorded during a recent 2017 weather event in Texas, United States (EPA, 2007). This concentration or higher levels have been used in several human clinical studies during intermittent exercise (Miller et al., 2016c). Although ozone concentration of 0.8ppm used i

• br Conclusion br Conflict of Interest br Author Contribution

  2024-05-09

  

  Conclusion Conflict of Interest Author Contributions Acknowledgements This work was supported by a research grant (SR/50/AS-14/2012) from the Department of Science and Technology, New Delhi, India to CMC and CSIR Senior Research Fellowship (09/013(0339)/2010-EMR-I) to SB. Introduction

• Fig A shows a schematic representation of

  2024-05-09

  

  Fig. 2A shows a schematic representation of histological results according to the Franklin and Paxinos Mouse Brain Atlas (2001). The black circles represent the sites of drug infusion that were on-target within the amygdala. Gray circles represent the animals that had infusion locations outside the

• br A Rs which were cloned and then

  2024-05-09

  

  A3Rs, which were cloned and then pharmacologically identified in the early 1990s, are expressed in multiple organs and peripheral tissues including p2x7 antagonist involved in inflammatory responses (Gessi et al., 2008, Borea et al., 2014). While low levels are expressed in the CNS, A3R agonists

• As noted earlier the PfkB

  2024-05-09

  

  As noted earlier, the PfkB family of carbohydrate kinases can phosphorylate the hydroxymethyl group of a wide variety of sugar moieties [1], [3]. Recent searches of the Swiss-Prot database with the two conserved sequence motifs found in these proteins (Accession nos. PS00583 and PS00584) identified

• Y-27632 In an effort to determine if one ARI was more

  2024-05-09

  

  In an effort to determine if one 5ARI was more effective than the other, the Enlarged Prostate International Comparator Study (EPICS) [17] compared treatment with finasteride and dutasteride in 1630 men over the age of 50 and concluded that after one year of treatment, both groups had statistically

• Finasteride has been shown to be

  2024-05-09

  

  Finasteride has been shown to be a mechanism-based inhibitor of 5AR-2 [9]. Finasteride acts as an alternate substrate for 5AR-2 and is initially bound in an extremely stable enzyme-bound NADP-dihydrofinasteride adduct which is ultimately processed to dihydrofinasteride. The NADP-dihydrofinasteride a

• br Introduction In the past

  2024-05-09

  

  Introduction In the past two decades, graphene and graphene based nanomaterials with unique physicochemical properties have attracted great attentions in many fields including biomedicine and biotechnology. Graphene oxide (GO) and its derivatives have shown promising potential as biological and c

• br Materials and methods br

  2024-05-09

  

  Materials and methods Results Discussion In this study, we administrated BDE-153 to newborn rat pups at PND 10 and cultured primary neurons, measured neuronal apoptosis and LDH activity in vivo and in vitro, then explored the possible predominant pathway underlying the neuronal apoptosis by

16400 records 158/1094 page Previous Next First page 上5页 156157158159160 下5页 Last page