• Arginase deficiency is a rare urea cycle

  2025-01-14

  

  Arginase deficiency is a rare urea cycle disorder with hyperargininemia and profound neurological impairment as hallmark features. Arginase-1-deficient mouse models have been created, and they exhibit a profound lethal phenotype approximately 2 weeks after birth in the global knockout (KO) mice or a

• The regulation of gene expression by glucocorticoids can be

  2025-01-14

  

  The regulation of gene expression by glucocorticoids can be mediated either by the canonical mechanism that involves the interaction of the glucocorticoid receptor (GR), a transcription factor activated by the hormone, with glucocorticoid response element (Ye et al., 2007), or by the non-canonical m

• br Genetic analysis of polarity complexes Model organisms su

  2025-01-14

  

  Genetic analysis of polarity complexes Model organisms such as Caenorhabditis elegans and Drosophila melanogaster provide useful means of describing basic biological processes. They lend themselves particularly well to addressing some of the questions arising in this field because of their struct

• Overexpression of AR in a transgenic mouse model leads

  2025-01-13

  

  Overexpression of AR in a transgenic mouse model leads to a capsular cataract phenotype involving proliferation and formation of a fibrotic plaque of cells reminiscent of cells at the posterior 366 2 in PCO [17]. To investigate the molecular mechanism that could link AR expression to this phenotype,

• In addition to it we also showed that glycine

  2025-01-13

  

  In addition to it, we also showed that glycine increases miR-301a expression which directly binds to PTEN 3′UTR target sites [13]. Glycine confers neuroprotection through microRNA-301a/PTEN signaling in rats cortical neurons in oxygen deprivation model [13]. Substantial studies indicate that inhibit

• The cavity volume of the binding

  2025-01-13

  

  The cavity volume of the binding pocket may differ not only between species but also among various AhR/ARNT isoforms within a single species. It is noteworthy that even a single amino isoquercitrin synthesis substitution within a binding pocket may result in a change in the cavity volume. This, in

• Adiponectin also works on AdipoR inducing extracellular Ca i

  2025-01-13

  

  Adiponectin also works on AdipoR1, inducing extracellular Ca2+ influx necessary for activation of Ca2+/calmodulin-dependent protein kinase kinase (CaMKK)β, AMPK (Fig. 1). This step is then followed by activation of SirT1 and increased expression and decreased acetylation of PPARγ coactivator (PGC)-1

• Patients with AAG often respond to intravenous immunoglobuli

  2025-01-13

  

  Patients with AAG often respond to intravenous immunoglobulin or plasma exchange. If these therapies are inadequate, ongoing immune suppression with steroids, azathioprine, mycophenylate or rituximab have been shown to be effective in case reports. Our patient seemed initially resistant to steroid t

• The presence of different LO splice variants was first

  2025-01-13

  

  The presence of different 5-LO splice variants was first demonstrated in human 5-moUTP modified mRNA tumour cells and in dimethyl sulfoxide-differentiated HL-60 cells [40] and a correlation between the 5-LO splicing pattern and the malignancy of the brain tumours was found. Later, other splice vari

• The first description of autophagy as

  2025-01-13

  

  The first description of autophagy as a tumour suppression process arises from the observation that the initial step regulatory gene, Atg6/BECN1, was monoallelically lost in 40% to 75% of human prostate, breast, and ovarian cancers [31]. However, while BECN1 heterozygous mutant mice develop, with lo

• Preliminary results of studies sponsored by the

  2025-01-13

  

  Preliminary results of studies sponsored by the manufacturer of ETC-1002 have also shown positive results for monotherapy in statin-intolerant patients and for the combined use of the ACL inhibitor plus other cholesterol-reducing agents. In patients with a documented history of intolerance to statin

• Angiogenesis refers to the formation of new

  2025-01-10

  

  Angiogenesis refers to the formation of new blood vessels from pre-existing vasculature [1]. Physiological angiogenesis is necessary for key processes such as wound healing, tissue regeneration and repair. In pathological conditions, including cardiovascular diseases, diabetes, cancer, and other pat

• br Results br Discussion Many tumor cells rely on EAAs

  2025-01-10

  

  Results Discussion Many tumor Elatericin B rely on EAAs to provide fundamental building blocks for macromolecular biosynthesis because they cannot synthesize EAAs de novo (Hattori et al., 2017; Sheen et al., 2011). Therefore, they must use highly effective transporters to maximize EAA uptake

• AKT activity is also self limiting through its substrate

  2025-01-10

  

  AKT activity is also self-limiting through its substrate GSK3β; the kinase activity of which is negatively regulated by AKT phosphorylation (Fig. 3; Li, Liu, & Gao, 2009). GSK3β activation results in phosphorylation and subsequent ubiquitin mediated degradation of PHLPP (Li et al., 2009). AKT activa

• In a recent series of studies from our

  2025-01-10

  

  In a recent series of studies from our laboratory, to characterize the contractile systems within the rat SW033291 wall, three conditions were identified that led to detrusor activity: spontaneous micro-contractions, electrical field stimulated (EFS) contractions and muscarinic agonist induced contr

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