• Mortality from breast cancer is almost always attributed to

  2022-09-20

  

  Mortality from breast cancer is almost always attributed to metastatic spread of the disease to other organs, thus precluding resection as a treatment method. Unfortunately, conventional chemotherapy fails to eradicate most human cancers, including aggressive breast cancers. Studies over the past de

• Gene expression of both GPR A and

  2022-09-20

  

  Gene expression of both GPR109A and GPR81 in adipocytes has been linked to PPARγ activation [22]. Treatment with the thiazolidinedione (TZD) PPARγ agonist, rosiglitazone, increases GPR109A and GPR81 expression, and knockdown of PPARγ suppresses receptor expression in fully differentiated human multi

• Although glycine receptors predominate in the brain stem and

  2022-09-19

  

  Although glycine receptors predominate in the brain stem and spinal cord, they are also expressed in higher brain regions such as the nucleus accumbens, frontal cortex, and hippocampus (Jonsson et al., 2012, Jonsson et al., 2009, Molander and Söderpalm, 2005b). A variety of drugs of abuse, including

• Next the effects of a phenyl group

  2022-09-17

  

  Next, the effects of a phenyl group at the 3- and 4-positions of the furan on GCGR affinity were investigated (). Surprisingly, despite the lack of a 4-phenyl group at the furan, compound exhibited almost the same GCGR affinity as compound . On the other hand, when the phenyl group at the 3-positio

• The mechanism by which Piezo acts in the regulation of

  2022-09-17

  

  The mechanism by which Piezo1 acts in the regulation of RBC volume is not firmly established. Its curved structure implies that it is activated by an increase in membrane tension (11), a mechanism indicated by electrophysiological measurements (16). However, the RBC membrane mechanics at its physiol

• In the thoracic spinal cord neither glacial

  2022-09-17

  

  In the thoracic spinal cord, neither glacial acetic beta lactamase inhibitor nor HBO2 had an effect on nNOS expression or expression of the phosphorylated β3 subunit of the GABAA receptor. This result was not unexpected due to the preponderance of nociceptive signaling in the lumbar versus thoracic

• The effect of GC on Fgf was not directly dependent

  2022-09-17

  

  The effect of GC on Fgf21 was not directly dependent on ileal Fgf15 because basal Fgf21 rna polymerase ii was similar in Fgf15+/+ and Fgf15−/− mice. Moreover, GC treatment induced similar Fgf21 up-regulation in both strains. Fxr activation has been reported to increase Fgf21 expression and secretio

• Compound and several additional FPR

  2022-09-17

  

  Compound 10 and several additional FPR1 antagonists identified here specifically blocked fMLF-induced responses mediated via FPR1 in FPR1-HL60 prostaglandin e and human neutrophils, but not responses mediated via FPR2 or FPR3 (in human neutrophils and transfected HL60 cells) or Fpr1 (murine neutrop

• br Site of expression FASTK is expressed in various

  2022-09-17

  

  Site of expression FASTK is expressed in various parts of human body including heart, skeletal muscle, brain, placenta, lung, liver, kidney pancreas (Ota et al., 2004) and many other organs (Fig. 1). It has been reported that FASTK is highly expressed in pancreatic tumors, where it is involved in

• Our results are consistent with the hypothesis

  2022-09-17

  

  Our results are consistent with the hypothesis that reduced Fas-mediated apoptosis in maternally activated T-lymphocytes could result in insufficient trophoblast invasion of the spiral Vinpocetine as the activated T-lymphocytes become able to enhance the destruction of the cytotrophoblasts. A reduce

• Our investigation also showed NAC increased the

  2022-09-17

  

  Our investigation also showed NAC increased the level of DAF and might protect HUVECs from complement activation. NAC, an antioxidant/mucous modifier, has displayed benefits in chronic obstructive pulmonary disease. Martinez de Lizarrondo et al [38] provided evidence that the molecular target underl

• In fact most PIs are susceptible to substitutions at Asp

  2022-09-16

  

  In fact, most PIs are susceptible to substitutions at Asp168, which are often present in patients who fail therapy (Pawlotsky, 2016). Notably, the polymorphism Gln168 at this position underlies reduced efficacy of PIs against GT3 (Soumana et al., 2016a). Glecaprevir and voxilaprevir have improved re

• The NF B family of transcription factors

  2022-09-16

  

  The NF-κB family of transcription factors is involved in acquisition of resistance to anticancer drugs as well as to apoptosis. NF-κB-mediated mdr1 gene upregulation is part of the anti-apoptotic protection mechanism of proximal tubule (PT) Ertapenem sodium salt synthesis against cadmium-induced ox

• The stress of accelerated lactate production

  2022-09-16

  

  The stress of accelerated lactate production in cancer CJ-42794 is moderated by the overexpression of lactate transporters – symporters for lactate anions and protons called monocarboxylate transporters (MCTs) – that are capable of bidirectional transport depending on the environmental and/or cellu

• The activation of AKT and ERK results in

  2022-09-16

  

  The activation of AKT and ERK1/2 results in the stabilization and increase in the co-transcriptional function of β-catenin [31], [32], [33]. Here, (R,R′)-MNF was found to reduce the levels of phospho-active AKT and ERK, which, in turn, may regulate the abundance and signaling potential of β-catenin.

16027 records 377/1069 page Previous Next First page 上5页 376377378379380 下5页 Last page