• To apply the recently developed GPR ligands

  2022-02-26

  

  To apply the recently developed GPR35 ligands to CNS disorders, it is necessary to understand whether GPR35 is expressed by any identified cell types in the 98 and whether activation or blockade of this receptor has any consequence on the activity of the neuronal circuitry. To this end, the present

• br Regulation of Glu transporters

  2022-02-26

  

  Regulation of Glu transporters The pivotal role of Glu transporters in the fine tuning and turnover of this excitatory amino Physcion calls for a detailed characterization of its regulation. Several general mechanisms that modify Glu uptake activity have been described. These include transcripti

• So far only few studies report about GAL

  2022-02-26

  

  So far only few studies report about GAL in the visual system: GAL has been detected in the cornea of rat (Jones and Marfurt, 1998), mouse (Henken and Martin, 1992) and pig (Stone et al., 1988), and in the uvea of rat (Strömberg et al., 1987), pig (Stone et al., 1988) and cat (Grimes et al., 1994),

• Acknowledgments This work was supported

  2022-02-26

  

  Acknowledgments This work was supported by the Natural Science Foundation of China (Nos. 21602254, 81603194), the Natural Science Foundation of Jiangsu province, China (BK20160767) and National Found for Fostering Talents of Basic Science (NFFTBS, J1310032). Introduction Glucocorticoids (GC) pl

• Some malignant human tumors cells also express FPRs

  2022-02-26

  

  Some malignant human tumors carnitine palmitoyltransferase also express FPRs and respond to bacterial or endogenous agonists by increased motility and growth. For instance, FPRs expressed by human gastric cancer cells, mediate epithelial–mesenchymal transition, cell proliferation, migration, and re

• iap apoptosis Our paper also contributes to

  2022-02-26

  

  Our paper also contributes to the large, but hitherto inconclusive literature that studies the effects of option-based compensation or convexity in compensation on corporate risk-taking policies. On the one hand, some studies document a positive relationship by showing that convexity increases lever

• Previous studies have shown that

  2022-02-26

  

  Previous studies have shown that ox-LDL-induced hepatic sinus dysfunction is the result of multiple pathways, multi-factorial regulation, and in the present study, we reported for the first time that ox-LDL regulates the basement membrane protein VN through the integrin αvβ5 pathway under high gluco

• Recent findings of us suggest that compounds that

  2022-02-26

  

  Recent findings of us suggest that compounds that inhibit both FAAH and TRPV1 may be more efficacious in pain relief than those targeting only one such protein. As continuation of our efforts to identify new molecules able to target simultaneously both FAAH and TRPV1 receptors, we hypothesized that

• Zileuton Recent advances in imaging single protein mobility

  2022-02-26

  

  Recent advances in imaging single protein mobility and organization in live organisms such as Drosophila larva motor nerve terminals have initiated this by providing a useful platform to investigate how the dynamic changes in the actomyosin network correlates with vesicle docking and fusion in vivo2

• br Acknowledgements and disclosures This work

  2022-02-25

  

  Acknowledgements and disclosures This work was supported in part by the National Institutes of Health (R01 HL-131673-01A1) and the Veterans Administration (BX-002539-01), United States. The authors have nothing to disclose concerning any conflict of interest. Introduction Adaptations are ofte

• Lastly certain populations of immune cells may be

  2022-02-25

  

  Lastly, certain populations of immune cells may be Hh responsive. Although PC have not been demonstrated in healthy liver-resident macrophages or lymphocytes, macrophages in injured livers have been shown to produce Hh ligands[58], [100], [101] and treating liver-derived macrophages with neutralisin

• Recently anti tumor or antiviral

  2022-02-25

  

  Recently, anti-tumor or antiviral strategies using RNAi for both gene silencing and innate-receptor activation were designed; one mechanism of these strategies is activating the intracellular retinoic acid–inducible gene I protein (RIG-I). 5′-Triphosphate RNA (3p-small interfering RNA [siRNA]) is th

• NPxY was recognized as the first short signal sequence

  2022-02-25

  

  NPxY was recognized as the first short signal sequence motif in the cytoplasmic domain of membrane receptors and proteins with critical roles in internalization and trafficking of receptor molecules [130]. Including LDL receptor, beta-1 integrin, megalin, beta-amyloid precursor protein, EGF receptor

• Although it has been observed in numerous studies and

  2022-02-25

  

  Although it has been observed in numerous studies and by many investigators that intraplatelet cGMP elevation results in platelet inhibition, there are a few papers which proposed a platelet stimulatory role for cGMP when elevated in response to NO donors or PDE5 inhibitors in mouse and human platel

• Selected GSNOR inhibitors were assessed for

  2022-02-25

  

  Selected GSNOR inhibitors were assessed for potential off-target activity with a panel of 54 transmembrane and soluble receptors, ion channels, and monoamine transporters. Off-target effects were estimated from the percent inhibition of receptor radio-ligand binding in the presence of 10μM of test c

16402 records 510/1094 page Previous Next First page 上5页 506507508509510 下5页 Last page