• br Acknowledgments I thank Takeshi Sakaba for critical

  2021-11-17

  

  Acknowledgments I thank Takeshi Sakaba for critical reading of the manuscript and helpful comments. This work was supported by JSPS/MEXT KAKENHI Grant Numbers 17K19466, 17H03548. Introduction The oral route of drug application is the main route in pharmacology since it is easy to handle and o

• To address this we developed approaches to image at high

  2021-11-17

  

  To address this, we developed approaches to image at high spatial and temporal resolution live WPB fusions as well as the release of VWF and other WPB cargo by spinning disk microscopy and combined laser ablation and total internal reflection fluorescence (TIRF) microscopy. Our live cell imaging rev

• In NAFLD models the first hit is liver

  2021-11-17

  

  In NAFLD models, the “first hit” is liver fat accumulation, which causes insulin resistance, whereas the interplay of inflammatory cytokines, which causes inflammation, acts as the representative “second hit” [9]. However, recently, the “multiple hit” hypothesis has taken into consideration that mul

• Two typical properties of Gi o protein coupled

  2021-11-17

  

  Two typical properties of Gi/o protein-coupled receptors, namely an increase in 35S-GTPγS binding (Strange, 2010) and an inhibition of exocytotic noradrenaline release (Schlicker and Göthert, 1998), were not shared by H4 receptor activation on cortical membranes (guinea-pig and mouse) and cortical s

• br Conclusion br Acknowledgments This

  2021-11-17

  

  Conclusion Acknowledgments This research was funded by Tianjin Health Institution Key Projects, grant number 15KG148” and “Tianjin Medical University General Hospital Youth Incubation Fund, grant number ZYYFY2017029”. I would like to express my heartfelt gratitude to Professor Hongtao Zhang fo

• Given the role that activation of GC C has

  2021-11-17

  

  Given the role that activation of GC-C has in stimulating fluid secretion in the intestine, attempts have been made to exploit this pathway to relieve symptoms of chronic constipation. Currently, an orally administered synthetic ST mimic, linaclotide [29], has been successfully shown to alleviate co

• Nitecapone br Conclusion Membrane transporters remain

  2021-11-16

  

  Conclusion Membrane transporters remain relatively understudied in human disease, especially TBI (Cesar-Razquin et al., 2015), and considerably less is known in terms of expression, function and substrates of membrane transporters in pediatric patients. However, their importance in maintaining Ni

• br Methods br Results and discussion br Conclusions A third

  2021-11-16

  

  Methods Results and discussion Conclusions A third example of a hexokinase using polyphosphate exclusively as a phosphoryl donor has been identified, this time in mammalian tissues. This is the first polyphosphate utilizing enzyme activity demonstrated in mammalian hyPerFUsion™ high-fideli

• br Ghrelin actions in the central

  2021-11-16

  

  Ghrelin actions in the central nervous system Ghrelin induces thymopoeisis GHS-R1a is expressed in immune cells, including thymocytes and T-cells [13]. Infusion of ghrelin increases the number of thymocytes and thymus size in 14-, 20-, and 24-month-old mice, and with decreased thymic adiposity

• Different from stable transfection transient

  2021-11-16

  

  Different from stable transfection, transient expression was also found to yield γ-secretase with robust proteolytic activity []. Co-transfection of all four, but not any three, components of human γ-secretase yielded high expression levels. This observation strongly suggests the co-folding nature o

• Some malignant human tumors cells also express FPRs

  2021-11-16

  

  Some malignant human tumors Eltrombopag Olamine also express FPRs and respond to bacterial or endogenous agonists by increased motility and growth. For instance, FPRs expressed by human gastric cancer cells, mediate epithelial–mesenchymal transition, cell proliferation, migration, and resistance to

• Recently Bristol Myers Squibb and Merck reported their GPR

  2021-11-16

  

  Recently, Bristol-Myers Squibb and Merck reported their GPR40 agonist research focused on the modification of α,β-position of phenylpropionic cftr channel derivatives. For example, in recent published patent applications, Bristol-Myers Squibb claimed the pyrrolidine and dihydropyrazole GPR40 agonist

• Mitochondria are also involved in other modalities

  2021-11-16

  

  Mitochondria are also involved in other modalities of programmed cell death, particularly apoptosis. Intriguingly, the roles of mitochondria in apoptosis and ferroptosis are fundamentally different. In mitochondria-mediated apoptosis, the mitochondrion serves as a reservoir, storing apoptosis-regula

• A common feature of ferroptosis is

  2021-11-16

  

  A common feature of ferroptosis is the iron-dependent accumulation of lipid-ROS and the subsequent depletion of polyunsaturated fatty ornidazole receptor phospholipids (PUFA-PLs) [118]. The PUFA chains of membrane lipids are more susceptible to both enzymatic and non-enzymatic oxidation, which resu

• Paroxysmal or sustained atrial fibrillations

  2021-11-16

  

  Paroxysmal or sustained atrial fibrillations profoundly activate platelets and induce coagulation factors in the heart (Choudhury and Lip, 2003). Accumulating factor Xa and downstream thrombin in the fibrillating left atrium activate PAR1 and/or PAR2 signaling to modulate electrical characteristics

16471 records 575/1099 page Previous Next First page 上5页 571572573574575 下5页 Last page