• RLS is a genetically complex disorder in which genetic and

  2021-08-24

  

  RLS is a genetically complex disorder in which genetic and environmental factors contribute to the phenotype (Trenkwalder, Allen, Högl, Paulus, & Winkelmann, 2016). This disease is highly familial and six genetic variants with single nucleotide polymorphisms have been identified by genome-wide assoc

• Introduction Angiotensin II Ang II and Endothelin

  2021-08-23

  

  Introduction Angiotensin II (Ang II) and Endothelin 1 (ET-1) are potent vasoconstrictive peptides recognized as key players in many cardiovascular diseases [1]. Cardiac hypertrophy, ischemic arrhythmia, and stroke have been associated to an overstimulation of the angiotensin II type 1 (AT1) recepto

• br The modulation of ER from SERMs to

  2021-08-23

  

  The modulation of ERα: from SERMs to TSECs Continued efforts to provide women with efficacious menopausal therapies have generated interest in the development of selective alkaline phosphatase inhibitor receptor modulators (SERMs). Similar to estrogens, SERMs have been shown to bind to ERs with

• A French cohort study reported

  2021-08-23

  

  A French cohort study reported that micronized progesterone or didrogesterone used with oral or percutaneous estradiol showed no increase or decrease in the risk of breast cancer compared to synthetic progestins for at least 4 years of treatment [22] and even after 8 years [23]. Although the results

• Thus based on our prior results above we

  2021-08-23

  

  Thus, based on our prior results above, we hypothesized that B cells derived from ESCs are also B-1 cells and HSC independent. To test this hypothesis, we induced mouse ESCs on OP9 stromal cells into B-progenitors and transplanted them into sublethally irradiated NOD/SCID/Il2rγcnull (NSG) neonates.

• Several studies have shown that independently of

  2021-08-23

  

  Several studies have shown that, independently of body-weight control, the central actions of leptin improve glycemic control in obese diabetic rat and mouse models [62]. For instance, restoration of OB-Rb expression in OB-Rb-deficient mice, and in particular in POMC neurons, was sufficient to norma

• PGE EP activation has been found to attenuate the activation

  2021-08-23

  

  PGE2-EP4 activation has been found to attenuate the activation of microglia and to prevent lipid peroxidation and pro-inflammatory gene expression in a murine model of lipopolysaccharide (LPS)-induced histamine receptor antagonist inflammation [15]. Moreover, PGE2/EP4 signaling has elicited a protec

• Interest in the PGE EP pathway is

  2021-08-23

  

  Interest in the PGE2/EP4 pathway is increasing given its diverse capability of regulating central nervous system activity [13]. EP4 has a protective function by reducing cerebral injury and improving functional outcome after stroke [14], and in suppressing Reversine synthesis inflammation [15]. The

• Nitrid oxide NO and its potential endogenous

  2021-08-23

  

  Nitrid oxide (NO) and its potential endogenous production as an endothelium-derived factor was the first gaseous molecule accepted to be a signaling mediator in the organism [4,5]. NO plays a key role in physiological regulation of the bet bromodomain and exerts physiological functions in the nervo

• In principle in vitro techniques for assessing

  2021-08-23

  

  In principle, in vitro techniques for assessing enzyme induction might include the use of cultured hepatocytes, precision-cut liver slices, immortalized Ginsenoside Rd lines (such as those derived from hepatomas) and reporter gene constructs (where appropriate cells are transfected with recombinant

• In conclusion we propose that

  2021-08-23

  

  In conclusion, we propose that UBE2T (FANCT) mutations define a FA subtype. This is also a rare example of a mutated E2 enzyme causing an inherited human disorder, like UBE2A. The p.Gln2Glu substitution is probably hypomorphic, as indicated by the fact that a siUBE2T knockdown made AP65P-hTERT Tadal

• br Experimental br Acknowledgments The

  2021-08-23

  

  Experimental Acknowledgments The work was supported in part by the National Research and Development Plan (2017YFD0200506), the National Natural Science Foundation of China (21472062 and 31701820), 111 Project B17019, and excellent doctoral dissertation cultivation Grant from Central China Nor

• vadadustat Taken together this study gives first insights

  2021-08-20

  

  Taken together, this study gives first insights into the complex effect of DNMT inhibition on pattern separation. Acute administration of RG108 enhanced pattern separation performance measured with the OPS task and increased Bdnf1 expression. However, this effect was only acute, and was not present

• br Biological roles of DGK br Summary and future perspective

  2021-08-20

  

  Biological roles of DGKϵ Summary and future perspectives The most 1625 segment of DGKϵ, comprised of residues 20–42, appears to have no role in binding the lipid substrate DAG or in the acyl chain specificity of substrate phosphorylation. Nevertheless, the sequence in this segment of DGKϵ is

• An AmDH is engineered by mutating two conserved

  2021-08-20

  

  An AmDH is engineered by mutating two conserved amino Nile Red residues in the active site of an amino acid dehydrogenase (AADH). Starting from the leucine dehydrogenase (LeuDH) from Bacillus stearothermophilus, substituting a serine and leucine at the K68 and N261 positions, respectively, resulted

16471 records 624/1099 page Previous Next First page 上5页 621622623624625 下5页 Last page